The role of nutritional and environmental alterations of epigenetics on Human health system


  • Muhammad Mazhar Fareed Government College University Faisalabad


Environmental epigenetics, cell level, nutrients, cancer


Environmental epigenetics depicts how natural elements influence cell epigenetics what's more, consequently, human wellbeing. Epigenetic marks modify the spatial conformity of chromatin to direct quality articulation. Ecological variables with epigenetic impacts incorporate practices, nourishment, furthermore, synthetic compounds and modern contaminations. Epigenetic systems are additionally embroiled during improvement in utero and at the cell level, so natural openings might hurt the baby by weakening the epigenome of the creating organic entity to change illness hazard further down the road. Paradoxically, bioactive food parts might trigger defensive epigenetic adjustments all through life, with right on time life sustenance being especially significant. Past their hereditary qualities, the general wellbeing status of an individual might be viewed as a coordination of numerous natural signs beginning at incubation furthermore, acting through epigenetic changes. This audit investigates how the climate influences the epigenome in wellbeing and infection, with a specific spotlight on the disease. Understanding the atomic impacts of conduct, supplements, and poisons may be applicable for creating protection techniques also, customized health programs. Moreover, by re-establishing cell separation, epigenetic drugs could address a likely procedure for the therapy of numerous sicknesses including cancer/malignant growth.


Download data is not yet available.


Aiken, C. E., Tarry-Adkins, J. L., & Ozanne, S. E. (2016). Transgenerational effects of maternal diet on metabolic and reproductive ageing. Mammalian Genome, 27(7), 430-439.

Alavian‐Ghavanini, A., & Rüegg, J. (2018). Understanding epigenetic effects of endocrine disrupting chemicals: from mechanisms to novel test methods. Basic & clinical pharmacology & toxicology, 122(1), 38-45.

Argente, J., Mehls, O., & Barrios, V. (2010). Growth and body composition in very young SGA children. Pediatric Nephrology, 25(4), 679-685.

Barker, D. J., & Clark, P. M. (1997). Fetal undernutrition and disease in later life. Reviews of reproduction, 2, 105-112.

Bishop, K. S., & Ferguson, L. R. (2015). The interaction between epigenetics, nutrition and the development of cancer. Nutrients, 7(2), 922-947.

Choi, S.-W., & Friso, S. (2010). Epigenetics: a new bridge between nutrition and health. Advances in nutrition, 1(1), 8-16.

Dashwood, R. H., & Ho, E. (2007). Dietary histone deacetylase inhibitors: from cells to mice to man. Paper presented at the Seminars in cancer biology.

Davis, C. D., & Ross, S. A. (2007). Dietary components impact histone modifications and cancer risk. Nutrition reviews, 65(2), 88-94.

DeSantis, C. E., Lin, C. C., Mariotto, A. B., Siegel, R. L., Stein, K. D., Kramer, J. L., . . . Jemal, A. (2014). Cancer treatment and survivorship statistics, 2014. CA: a cancer journal for clinicians, 64(4), 252-271.

Doherty, S., Grabowski, J., Hoffman, C., Ng, S., & Zelikoff, J. (2009). Early life insult from cigarette smoke may be predictive of chronic diseases later in life. Biomarkers, 14(sup1), 97-101.

Druesne, N., Pagniez, A., Mayeur, C., Thomas, M., Cherbuy, C., Duée, P.-H., . . . Chaumontet, C. (2004). Diallyl disulfide (DADS) increases histone acetylation and p21 waf1/cip1 expression in human colon tumor cell lines. Carcinogenesis, 25(7), 1227-1236.

Ducci, F., & Goldman, D. (2008). Genetic approaches to addiction: genes and alcohol. Addiction, 103(9), 1414-1428.

Fabiani, R., Minelli, L., Bertarelli, G., & Bacci, S. (2016). A western dietary pattern increases prostate cancer risk: a systematic review and meta-analysis. Nutrients, 8(10), 626.

Farris, S. P., Wolen, A. R., & Miles, M. F. (2010). Using expression genetics to study the neurobiology of ethanol and alcoholism. International review of neurobiology, 91, 95-128.

Ford, D., Ions, L. J., Alatawi, F., & Wakeling, L. A. (2011). The potential role of epigenetic responses to diet in ageing. Proceedings of the Nutrition Society, 70(3), 374-384.

Fung, T., Hu, F. B., Fuchs, C., Giovannucci, E., Hunter, D. J., Stampfer, M. J., . . . Willett, W. C. (2003). Major dietary patterns and the risk of colorectal cancer in women. Archives of internal medicine, 163(3), 309-314.

Grunstein, M. (1997). Histone acetylation in chromatin structure and transcription. nature, 389(6649), 349-352.

Guerrero-Bosagna, C., & Skinner, M. K. (2012). Environmentally induced epigenetic transgenerational inheritance of phenotype and disease. Molecular and cellular endocrinology, 354(1-2), 3-8.

Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., . . . Lumey, L. (2008). Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proceedings of the National Academy of Sciences, 105(44), 17046-17049.

Huang, B., Jiang, C., & Zhang, R. (2014). Epigenetics: the language of the cell? Epigenomics, 6(1), 73-88.

Hussey, B., Lindley, M. R., & Mastana, S. (2017). Epigenetics and epigenomics: the future of nutritional interventions? : Future Science.

Jensen, V. S., Hvid, H., Damgaard, J., Nygaard, H., Ingvorsen, C., Wulff, E. M., . . . Fledelius, C. (2018). Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague–Dawley rats. Diabetology & metabolic syndrome, 10(1), 1-13.

Kim, K.-c., Friso, S., & Choi, S.-W. (2009). DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. The Journal of nutritional biochemistry, 20(12), 917-926.

Knopik, V. S., Maccani, M. A., Francazio, S., & McGeary, J. E. (2012). The epigenetics of maternal cigarette smoking during pregnancy and effects on child development. Development and psychopathology, 24(4), 1377-1390.

Kouzarides, T. (1999). Histone acetylases and deacetylases in cell proliferation. Current opinion in genetics & development, 9(1), 40-48.

Larsson, S. C., Giovannucci, E., & Wolk, A. (2006). Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology, 131(4), 1271-1283.

Lillycrop, K. A., Hoile, S. P., Grenfell, L., & Burdge, G. C. (2014). DNA methylation, ageing and the influence of early life nutrition. Proceedings of the Nutrition Society, 73(3), 413-421.

Lo Re, O., & Vinciguerra, M. (2017). Histone MacroH2A1: a chromatin point of intersection between fasting, senescence and cellular regeneration. Genes, 8(12), 367.

Malvezzi, M., Bertuccio, P., Rosso, T., Rota, M., Levi, F., La Vecchia, C., & Negri, E. (2015). European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women? Annals of Oncology, 26(4), 779-786.

Pal, S., & Tyler, J. (2016). Epigenetics and aging. Sci Adv 2: e1600584.

Rando, O. J., & Simmons, R. A. (2015). I’m eating for two: parental dietary effects on offspring metabolism. Cell, 161(1), 93-105.

Reamon-Buettner, S. M., Mutschler, V., & Borlak, J. (2008). The next innovation cycle in toxicogenomics: environmental epigenetics. Mutation Research/Reviews in Mutation Research, 659(1-2), 158-165.

Strohsnitter, W. C., Noller, K. L., Hoover, R. N., Robboy, S. J., Palmer, J. R., Titus-Ernstoff, L., . . . Hatch, E. E. (2001). Cancer risk in men exposed in utero to diethylstilbestrol. Journal of the National Cancer Institute, 93(7), 545-551.

Struhl, K. (1998). Histone acetylation and transcriptional regulatory mechanisms. Genes & development, 12(5), 599-606.



How to Cite

Fareed, M. M. (2022). The role of nutritional and environmental alterations of epigenetics on Human health system. European Journal of Volunteering and Community-Based Projects, 1(1), 38-51. Retrieved from