The Immunoinformatic, Structural elucidation of ULBP2 Protein in the therapeutics of Tumorigenesis: Using Bioinformatics Approaches : Immunoinformatic analysis of ULBP2 against the cancer treatment

Muhammad Mazhar Fareed; Khazeema  Yousaf; Muhammad  Salman Akber; Muhammad  Mohsin Ali

Authors

Muhammad Mazhar Fareed Government College University Faisalabad
Khazeema Yousaf Department of Biotechnology, Lahore College for Women University
Muhammad Salman Akber Faculty of Life Sciences, Department of Bioinformatics and Biotechnology, Government College University
Muhammad Mohsin Ali Faculty of Medical Sciences, Department of Physical therapy, Government College University Faisalabad, Pakistan

Keywords:

Cancer, B cell epitope, ULBP2, T cell epitope, bioinformatics

Abstract

The Natural killer (NK) cells' ability to destroy cancerous cells is predominantly focused on the activation of the co-stimulatory and natural killer group two with receptor of member-D also called NKGD2/NKG2D. These identifies ligands that are MHC-Class1 structural homologs like that of the UL16 protein-binding type 2. The ULBP2 has been shown to mediate-natural resistance against the tumors mechanism in the condition of in-vitro, in-vivo, making it a possible target for producing the immune-therapeutic drugs for the diagnosis of the cancers and certain other viral diseases. In this present research, we created a stable and high-quality 3-D structure of the ULBP-2 protein through SWISS-Model also visualized by using UCSF-Chimera Tool. Moreover, the ULBP2 protein was prognosticated to be acts as antigenic, 11-discontinuous-B-Cell epitopes, 05 ULBP2 proteins antibody-based epitopes, and possible predicted the top hits of six linear B-cell epitopes. The ULBP2 protein carried seven cytotoxic-T lymphocytes (CTLs), two helper-T lymphocytes (HTLs), the LGKKLNVTTAWAQN is a promiscuous epitope MHC bounded to the T cells and with LRDIQLENY highest antigen scores in MHC molecule. Finally, the promising epitopes that could be successful in producing B-cell and T-cell mediated immunity against the required immune reaction to tumorigenesis were expected.

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The Immunoinformatic, Structural elucidation of ULBP2 Protein in the therapeutics of Tumorigenesis: Using Bioinformatics Approaches

Immunoinformatic analysis of ULBP2 against the cancer treatment

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